Search on: NOD LIKE RECEPTORS 
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Descriptor English:   NLR Proteins 
Descriptor Spanish:   Proteínas NLR 
Descriptor Portuguese:   Proteínas NLR 
Synonyms English:   NLR Protein
NOD-like Receptors
Nucleotide-binding Domain Leucine-rich Repeat Proteins
NOD like Receptors
Nucleotide binding Domain Leucine rich Repeat Proteins
Protein, NLR
Proteins, NLR
Receptors, NOD-like  
Tree Number:   D12.644.360.539
Definition English:   Intracellular signaling proteins that are defined by the presence of a NUCLEOTIDE-binding region and LEUCINE-rich repeats. Their general structure consists of any of a variety of effector domains at their N-termini such as a caspase recruitment domain (CARD), a central nucleotide-binding domain, and a variable number of C-terminal leucine-rich repeats. They are important for pathogen recognition in the INNATE IMMUNE RESPONSE of animals and plants. Members of the NLR protein family include the NOD SIGNALING ADAPTOR PROTEINS. 
History Note English:   2017 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   56549 
Unique Identifier:   D000070576 

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